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KMID : 0380620130450030385
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Korean Journal of Food Science and Technology
2013 Volume.45 No. 3 p.385 ~ p.390
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Effect of Tuna Extracts on Production of Nitric Oxide and Inflammatory Cytokines
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Kim Kwang-Hyuk
Choi Myung-Won
Choi Hyang-Mi
Lim Sun-Young
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Abstract
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The effect of tuna extracts on the production of nitric oxide (NO) and cytokines including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), was investigated. All extracts and fractions from tuna significantly reduced NO production induced by lipopolysaccharide (LPS). The acetone+methylene chloride (A+M) extract, n-hexane and 85% aqueous methanol (MeOH) fractions had stronger inhibitory effects among them. The 85% aqueous MeOH fraction at a 10-μg concentration significantly decreased LPS-induced IL-6 and TNF-α productions at 6 h of incubation. In the case of LPS-induced IFN-γ production, the 85% aqueous MeOH fraction at a 3-μg concentration showed significantly higher levels at 48 h of incubation. These results show that the 85% aqueous MeOH fraction inhibited the production of NO and pro-inflammatory cytokines (IL-6, TNF-α), suggesting that this fraction acts as a potent immunomodulator.
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KEYWORD
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tuna extract, nitric oxide, interleukin-6, tumor necrosis factor-α, interferon-γ
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